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PHAP Polyclonal Antibody
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FIGURE: 1 / 3
PHAP Antibody (BS-6083R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with PHAP Polyclonal Antibody, Unconjugated (bs-6083R) at 1:400 overnight at 4°C, DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
BS-6083R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PHAP1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acid nuclear phosphoprotein 32 (leucine rich); acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; acidic nuclear phosphoprotein 32; acidic nuclear phosphoprotein pp32; acidic protein rich in leucines; cerebellar leucine rich acidic nuclear protein; cerebellar postnatal development protein 1; epididymis secretory sperm binding protein; hepatopoietin Cn; I1PP-2A; inhibitor-1 of protein phosphatase-2A; LANP-L; LANP-like protein; leucine-rich acidic nuclear protein; leucine-rich acidic nuclear protein LANP; leucine-rich acidic nuclear protein like; mapmodulin; potent heat-stable protein phosphatase 2A inhibitor I1PP2A; proliferation related acidic leucine rich protein PAL31; proliferation-related acidic leucine-rich protein PAL31; putative HLA-DR-associated protein I; putative HLA-DR-associated protein I-2; putative human HLA class II associated protein I; silver-stainable protein SSP29; unnamed protein product; vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Gene Aliases: 2410015B15Rik; 2810018A15Rik; Anp32; APRIL; C15orf1; CPD1; HPPCn; I1PP2A; LANP; LANP-L; LANPL; MAPM; mLANP-L; PAL31; PHAP1; PHAPI; PHAPI2; PHAPI2a; PP32; SSP29
UniProt ID: (Human) P39687, (Human) Q92688, (Human) Q9BTT0, (Mouse) O35381, (Rat) P49911, (Mouse) Q9EST5, (Rat) Q9EST6, (Mouse) P97822, (Rat) Q5XIE0
Entrez Gene ID: (Human) 8125, (Human) 10541, (Human) 81611, (Mouse) 11737, (Rat) 25379, (Mouse) 67628, (Rat) 170724, (Mouse) 66471, (Rat) 361999
nucleocytoplasmic transport
negative regulation of protein modification process
regulation of apoptotic process
negative regulation of plasma membrane bounded cell projection assembly
base-excision repair
granzyme-mediated apoptotic signaling pathway
intracellular signal transduction
regulation of transferase activity
protein folding
G1/S transition of mitotic cell cycle
vasculature development
nucleosome assembly
positive regulation of cell proliferation
ventricular system development
negative regulation of apoptotic process
negative regulation of cell differentiation
positive regulation of protein export from nucleus
inner ear development
palate development
positive regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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