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Invitrogen
PHAP Polyclonal Antibody
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Product Details
PA5-20024
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to amino acids at amino terminus of human PHAP.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is Raji cell lysate.
PA5-20024 can be used with blocking peptide PEP-0143.
Target Information
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acid nuclear phosphoprotein 32 (leucine rich); acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; Acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic leucine-rich nuclear phosphoprotein 32 family member B; Acidic leucine-rich nuclear phosphoprotein 32 family member E; acidic nuclear phosphoprotein 32; acidic nuclear phosphoprotein 32 family, member A; acidic nuclear phosphoprotein 32 family, member B; Acidic nuclear phosphoprotein pp32; Acidic protein rich in leucines; cerebellar leucine rich acidic nuclear protein; Cerebellar postnatal development protein 1; epididymis secretory sperm binding protein; hepatopoietin Cn; I1PP-2A; inhibitor-1 of protein phosphatase-2A; LANP; LANP-L; LANP-like protein; Leucine-rich acidic nuclear protein; leucine-rich acidic nuclear protein LANP; leucine-rich acidic nuclear protein like; Mapmodulin; PHAPI; PHAPI2; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; pp32; proliferation related acidic leucine rich protein PAL31; Proliferation-related acidic leucine-rich protein PAL31; Putative HLA-DR-associated protein I; Putative HLA-DR-associated protein I-2; putative human HLA class II associated protein I; Silver-stainable protein SSP29; unnamed protein product; vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Gene Aliases: 2410015B15Rik; 2810018A15Rik; AI047746; AI326868; Anp32; ANP32A; ANP32B; ANP32E; APRIL; C15orf1; CPD1; HPPCn; I1PP2A; LANP; LANP-L; LANPL; MAPM; mLANP-L; PAL31; PHAP1; PHAPI; PHAPI2; PHAPI2a; PP32; SSP29; W91701
UniProt ID: (Human) P39687, (Human) Q92688, (Human) Q9BTT0, (Rat) P49911, (Mouse) O35381, (Mouse) Q9EST5, (Rat) Q9EST6, (Mouse) P97822, (Rat) Q5XIE0
Entrez Gene ID: (Human) 8125, (Human) 10541, (Human) 81611, (Rat) 25379, (Mouse) 11737, (Mouse) 67628, (Rat) 170724, (Mouse) 66471, (Rat) 361999
RNA binding
protein binding
histone binding
RNA polymerase binding
phosphatase inhibitor activity
protein binding involved in protein folding
histone chaperone activity
protein C-terminus binding
cytoskeletal protein binding
cell adhesion molecule binding
chromatin/chromatin-binding, or -regulatory protein
nucleocytoplasmic transport
intracellular signal transduction
regulation of apoptotic process
vasculature development
nucleosome assembly
ventricular system development
negative regulation of apoptotic process
negative regulation of cell differentiation
positive regulation of protein export from nucleus
inner ear development
palate development
chromatin organization
protein folding
transcription, DNA-templated
regulation of transcription, DNA-templated
G1/S transition of mitotic cell cycle
positive regulation of cell proliferation
positive regulation of G1/S transition of mitotic cell cycle
activation of cysteine-type endopeptidase activity involved in apoptotic process
chromatin modification
negative regulation of catalytic activity
histone exchange
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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