|Western Blot (WB)||1-2 µg/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||19 amino acid peptide near the amino terminus of human PHC3|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A recommended positive control is NIH-3T3 cell lysate.
At least six isoforms of PHC3 are known to exist.
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: early development regulator 3; Early development regulatory protein 3; EDR3; Homolog of polyhomeotic 3; HPH3; PH3; polyhomeotic 3; polyhomeotic like 3; Polyhomeotic-like protein 3
Gene Aliases: E030046K01Rik; EDR3; HPH3; PH3; PHC3
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