HIF prolyl hydroxylase 2 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HPH-2, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It hydroxylates HIF-1 alpha at Pro(402) and Pro(564), and HIF-2 alpha. It targets HIF through the hydroxylation for proteasomal degredation via the von Hippel-Lindau ubiquitylation complex.
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Protein Aliases: Egl nine homolog 1; egl nine-like protein 1; egl-9 family hypoxia-inducible factor 1; HIF prolyl hydroxylase 2; HIF-PH2; HIF-prolyl hydroxylase 2; Hypoxia-inducible factor prolyl hydroxylase 2; PHD2; Prolyl hydroxylase domain-containing protein 2; SM-20; zinc finger MYND domain-containing protein 6
Gene Aliases: AI503754; C1orf12; ECYT3; EGLN1; HALAH; Hif-p4h-2; HIF-PH2; HIFPH2; HPH-2; HPH2; ORF13; PHD-2; PHD2; PNAS-118; PNAS-137; SM-20; SM20; ZMYND6