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PHEX Polyclonal Antibody
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FIGURE: 1 / 1
PHEX Antibody (BS-12313R) in Flow
A549 cells were fixed with 4% PFA for 10min at room temperature, permeabilized with 20% PBST for 20 min at room temperature, and incubated in 5% BSA blocking buffer for 30 min at room temperature. Cells were then stained with PHEX Polyclonal Antibody (bs-12313R)at 1:500 dilution in blocking buffer and incubated for 30 min at room temperature, washed twice with 2%BSA in PBS, followed by secondary antibody incubation for 40 min at room temperature. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green), and... View More
Product Details
BS-12313R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PHEX, amino acids 201-300.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HYP; Metalloendopeptidase homolog PEX; Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein); PEX; PHEX peptidase; phosphate regulating endopeptidase homolog X-linked; phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets); Phosphate regulating neutral endopeptidase; Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH); phosphate-regulating neutral endopeptidase; Phosphate-regulating neutral endopeptidase PHEX; similar to metalloendopeptidase; unnamed protein product; Vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein; X-linked hypophosphatemic rickets candidate gene product; X-linked phosphate regulating endopeptidase
Gene Aliases: Gy; HPDR; HPDR1; HYP; HYP1; LXHR; PEX; PHEX; XLH
UniProt ID: (Human) P78562, (Mouse) P70669
Entrez Gene ID: (Human) 5251, (Mouse) 18675, (Rat) 25512
skeletal system development
proteolysis
cell-cell signaling
protein processing
organophosphate metabolic process
bone mineralization
lung development
biomineral tissue development
response to vitamin D
protein modification process
odontogenesis
bone development
response to growth hormone
cellular response to vitamin D
cellular response to parathyroid hormone stimulus
response to sodium phosphate
response to insulin-like growth factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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