Immunogen sequence: ACTQCLSKPL LYGDRFYEFE CCVCRGGPEK VRRLQLRWVD VAHLVLYHLS VCCKKKYFDF DREILPFTSE NWDSLLLGEL SDTPKGERSS KLLSALNSHK DRFISGREIK KRKCLFGLHA RMPPPVEPPT GDGALTS
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.
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Protein Aliases: hPCl1; MTF2L2; PCL1; PHD finger protein 1; PHF2; Polycomb-like protein 1; Protein PHF1; testicular tissue protein Li 140; tudor domain containing 19C
Gene Aliases: hPHF1; MTF2L2; PCL1; PHF1; PHF2; TDRD19C
UniProt ID: (Human) O43189
Entrez Gene ID: (Human) 5252
Molecular Function: nucleic acid binding