Immunogen sequence: MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR WVDVAHLVLY; Positive Samples: A-549, HeLa, Mouse lung; Cellular Location: Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center
This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.
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Protein Aliases: hPCl1; mPCl1; PHD finger protein 1; polycomb-like 1; Polycomb-like protein 1; Protein PHF1; T-complex testis-expressed 3; testicular tissue protein Li 140; tudor domain containing 19C
Gene Aliases: AW557215; D17Ertd455e; hPHF1; MTF2L2; PCL1; PHF1; PHF2; Plc1; Tctex-3; Tctex3; TDRD19C
Molecular Function: nucleic acid binding