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Proteintech
PHF17 Polyclonal Antibody
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Product Details
15032-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PHF17 Fusion Protein Ag4290 (1-300 aa encoded by BC032376)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Amount
25.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKRGRLPSS SEDSDDNGSL STTWSQNSRS QHRRSSCSRH EDRKPSEVFR TDLITAMKLH DSYQLNPDEY YVLADPWRQE WEKGVQVPVS PGTIPQPVAR VVSEEKSLMF IRPKKYIVSS GSEPPELGYV DIRTLADSVC RYDLNDMDAA WLELTNEEFK EMGMPELDEY TMERVLEEFE QRCYDNMNHA IETEEGLGIE YDEDVVCDVC QSPDGEDGNE MVFCDKCNIC VHQACYGILK VPEGSWLCRT CALGVQPKCL LCPKKGGAMK PTRSGTKWVH VSCALWIPEV SIGSPEKMEP I (1-300 aa encoded by BC032376)
Target Information
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: apoptosis and differentiation in epithelia 1; gene for apoptosis and differentiation in epithelia; Jade family PHD finger protein 1; Jade1 PHD finger protein; PHD finger protein 17; PHD protein Jade-1; Protein Jade-1; unnamed protein product
Gene Aliases: AU041499; D530048A03Rik; JADE1; KIAA1807; mKIAA1807; PHF17
UniProt ID: (Human) Q6IE81, (Mouse) Q6ZPI0
Entrez Gene ID: (Human) 79960, (Mouse) 269424, (Rat) 310352
transcription coactivator activity
protein binding
zinc ion binding
histone acetyltransferase activity (H3-K14 specific)
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K12 specific)
metal ion binding
histone acetyltransferase activity (H4-K16 specific)
RNA polymerase II transcription coactivator activity
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
regulation of cell growth
regulation of DNA replication
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
negative regulation of cell growth
positive regulation of transcription, DNA-templated
regulation of cell cycle
negative regulation of canonical Wnt signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
regulation of DNA biosynthetic process
transcription, DNA-templated
transcription from RNA polymerase II promoter
histone H3 acetylation
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K12 acetylation
positive regulation of transcription from RNA polymerase II promoter
histone H4-K16 acetylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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