Recommended positive controls: A549, HeLa, HepG2.
Predicted reactivity: Mouse (97%), Rat (99%), Rhesus Monkey (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). [UniProt]
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Protein Aliases: gene for apoptosis and differentiation in epithelia; Jade family PHD finger protein 1; PHD finger protein 17; PHD protein Jade-1; Protein Jade-1
Gene Aliases: JADE1; KIAA1807; PHF17
UniProt ID: (Human) Q6IE81
Entrez Gene ID: (Human) 79960