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Product Details
15109-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PHKG2 Fusion Protein Ag6829 (1-298 aa encoded by BC002541)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTLDVGPED ELPDWAAAKE FYQKYDPKDV IGRGVSSVVR RCVHRATGHE FAVKIMEVTA ERLSPEQLEE VREATRRETH ILRQVAGHPH IITLIDSYES SSFMFLVFDL MRKGELFDYL TEKVALSEKE TRSIMRSLLE AVSFLHANNI VHRDLKPENI LLDDNMQIRL SDFGFSCHLE PGEKLRELCG TPGYLAPEIL KCSMDETHPG YGKEVDLWAC GVILFTLLAG SPPFWHRRQI LMLRMIMEGQ YQFSSPEWDD RSSTVKDLIS RLLQVDPEAR LTAEQALQHP FFERCEGSQ (1-298 aa encoded by BC002541 )
Target Information
PHKG2 is a testis/liver isoform of the phosphorylase kinase gamma subunit. Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by PHKG2. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in PHKG2 cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in PHKG2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PHK-gamma-LT; PHK-gamma-T; Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; phosphorylase b kinase gamma catalytic chain, testis/liver isoform; phosphorylase kinase; phosphorylase kinase gamma subunit 2; phosphorylase kinase subunit gamma 2; Phosphorylase kinase subunit gamma-2; phosphorylase kinase, gamma 2 (testis); Phosphorylase kinase, gamma 2 (testis/liver); PSK-C3; serine/threonine-protein kinase PHKG2
Gene Aliases: 1500017I02Rik; GSD9C; PHKG2
UniProt ID: (Human) P15735, (Rat) P31325, (Mouse) Q9DB30
Entrez Gene ID: (Human) 5261, (Rat) 140671, (Mouse) 68961
protein serine/threonine kinase activity
phosphorylase kinase activity
calmodulin binding
ATP binding
enzyme binding
tau-protein kinase activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
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