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PHOX2A Polyclonal Antibody
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Product Details
600-401-DM4
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-PHOX2A antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide near the C-terminus of human PHOX2A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aristaless homeobox gene homolog; aristaless homeobox homolog; Aristaless homeobox protein homolog; arix homeodomain protein; ARIX1 homeodomain protein; paired mesoderm homeobox 2a; Paired mesoderm homeobox protein 2A; Paired-like homeobox 2A; PHOX2A homeodomain protein; unnamed protein product
Gene Aliases: ARIX; CFEOM2; FEOM2; NCAM2; Phox2; PHOX2A; Pmx2; PMX2A
UniProt ID: (Human) O14813, (Mouse) Q62066, (Rat) Q62782
Entrez Gene ID: (Human) 401, (Mouse) 11859, (Rat) 116648
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
sequence-specific DNA binding
homeodomain transcription factor
noradrenergic neuron differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
somatic motor neuron differentiation
oculomotor nerve formation
trochlear nerve formation
locus ceruleus development
midbrain development
regulation of respiratory gaseous exchange
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
parasympathetic nervous system development
neuron development
dopaminergic neuron differentiation
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
aging
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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