Recommended positive controls: 293T, A431, HeLaS3.
Predicted reactivity: Mouse (100%), Xenopus laevis (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NBPhox; neuroblastoma paired-type homeobox protein; Neuroblastoma Phox; paired mesoderm homeobox 2b; Paired mesoderm homeobox protein 2B; Paired-like homeobox 2B; PHOX2B homeodomain protein
Gene Aliases: NBLST2; NBPhox; PHOX2B; PMX2B
UniProt ID: (Human) Q99453
Entrez Gene ID: (Human) 8929
Molecular Function: homeodomain transcription factor