Invitrogen

PHOX2B Polyclonal Antibody

View all (9) PHOX2B antibodies

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PHOX2B Antibody in Western Blot (WB) — Western blot analysis of PHOX2B on rat stomach tissue lysate. The sample was probed with a PHOX2B polyclonal antibody (Product # PA5-68966) using a primary antibody dilution of 1.0 µg/mL.

Product Details

PA5-68966

Applications	Tested Dilution	Publications
Western Blot (WB)	1.0 µg/mL	-

Product Specifications
Species Reactivity	Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	synthetic peptide directed towards the N-terminal region of rat PHOX2B
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5-1.0 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS with 2% sucrose
Contains	0.09% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2690156

Product Specific Information

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Target Information

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: neuroblastoma Phox; paired mesoderm homeobox protein 2B

Gene Aliases: NBPhox

Entrez Gene ID: (Rat) 364152

Molecular Function: homeodomain transcription factor

neuron migration regulation of respiratory gaseous exchange by neurological system process noradrenergic neuron differentiation noradrenergic neuron development brainstem development biological_process negative regulation of cell proliferation glial cell differentiation regulation of gene expression cell differentiation in hindbrain medullary reticular formation development hindbrain tangential cell migration neuron differentiation skeletal muscle cell differentiation negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter cell development autonomic nervous system development enteric nervous system development sympathetic nervous system development parasympathetic nervous system development inner ear development efferent axon development in a lateral line nerve respiratory system development retrotrapezoid nucleus neuron differentiation sympathetic ganglion development dopaminergic neuron differentiation cellular response to BMP stimulus neural crest cell migration involved in autonomic nervous system development

Process(es)

RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function DNA binding