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Product Details
PA5-54283
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PHPT1
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2645523
Product Specific Information
Immunogen sequence: DLALIPDVDI DSDGVFKYVL IRVHSAPRSG APAAESKEIV RGYKWAEYHA DIYDKVSGDM QKQGCDCECL GGGRISHQSQ DKKIHVYGYS MAYGPAQHAI STEKIKAKYP DYE
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 14 kDa phosphohistidine phosphatase; epididymis secretory sperm binding protein Li 132P; Phosphohistidine phosphatase 1; PHP; PHPT1; Protein histidine phosphatase; Protein janus-A homolog; PTPH1; sex-regulated protein janus-a
Gene Aliases: CGI-202; HEL-S-132P; HSPC141; PHP14; PHPT1
UniProt ID: (Human) Q9NRX4
Entrez Gene ID: (Human) 29085
protein dephosphorylation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
peptidyl-histidine dephosphorylation
negative regulation of T cell receptor signaling pathway
negative regulation of lyase activity
positive regulation of cell motility
regulation of actin cytoskeleton reorganization
negative regulation of ATP citrate synthase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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