This target displays homology in the following species: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 86%
The protein encoded by this gene is a member of the protein tyrosine phosphatase family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: 14 kDa phosphohistidine phosphatase; 14kDa phosphohistidine phosphatase; cytoskeletal-associated protein tyrosine phosphatase; epididymis secretory sperm binding protein Li 132P; Phosphohistidine phosphatase 1; PHP; PHPT1; Protein histidine phosphatase; Protein janus-A homolog; protein-tyrosine phosphatase H1; PTPH1; sex-regulated protein janus-a; tyrosine-protein phosphatase non-receptor type 3
Gene Aliases: 1700008C22Rik; BOS_12268; CGI-202; HEL-S-132P; HSPC141; PHP14; PHPT1; wu:fb50e08; zgc:101086