This target displays homology in the following species: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 86%
The protein encoded by this gene is a member of the protein tyrosine phosphatase family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: 14 kDa phosphohistidine phosphatase; Phosphohistidine phosphatase 1; PHP; PHPT1; Protein histidine phosphatase; PTPH1
Gene Aliases: 1700008C22Rik; Php14; Phpt1
UniProt ID: (Mouse) Q9DAK9
Entrez Gene ID: (Mouse) 75454