Bioss

PI3KCA Polyclonal Antibody

View all (40) PIK3CA antibodies

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Datasheet
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PI3KCA Polyclonal Antibody

Product Details

BS-2067R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rabbit, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human PI3KCA, amino acids 961-1068.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.1.153; EC:2.7.11.1; GRB1; MGC142161; MGC142163; p110alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K; PI3K alpha; PI3K-alpha; PI3Kalpha; pi3kca; PIK3R1; pk3ca; ptdIns-3-kinase p110; ptdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA

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Gene Aliases: 6330412C24Rik; caPI3K; CLOVE; CWS5; MCAP; MCM; MCMTC; p110; p110-alpha; p110alpha; PI3K; PI3K-alpha; PIK3CA

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UniProt ID: (Bovine) P32871, (Human) P42336, (Mouse) P42337, (Rat) A0A0G2K344

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Entrez Gene ID: (Bovine) 282306, (Rabbit) 100337822, (Human) 5290, (Mouse) 18706, (Rat) 170911

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Function(s)
protein serine/threonine kinase activity protein binding ATP binding protein kinase activator activity phosphatidylinositol 3-kinase activity insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphatidylinositol-3,4-bisphosphate 5-kinase activity kinase activity 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups phosphotransferase activity, alcohol group as acceptor kinase
Process(es)
angiogenesis liver development glucose metabolic process protein phosphorylation phagocytosis regulation of gene expression activation of protein kinase activity positive regulation of peptidyl-serine phosphorylation regulation of multicellular organism growth regulation of cellular respiration protein kinase B signaling negative regulation of neuron apoptotic process hypomethylation of CpG island phosphatidylinositol phosphorylation adipose tissue development cellular response to glucose stimulus energy homeostasis negative regulation of fibroblast apoptotic process regulation of genetic imprinting negative regulation of anoikis vasculature development phosphatidylinositol biosynthetic process epidermal growth factor receptor signaling pathway regulation of phosphatidylinositol 3-kinase signaling platelet activation T cell costimulation phosphatidylinositol-3-phosphate biosynthetic process insulin receptor signaling pathway via phosphatidylinositol 3-kinase Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis ERBB2 signaling pathway endothelial cell migration vascular endothelial growth factor receptor signaling pathway phosphatidylinositol-mediated signaling T cell receptor signaling pathway leukocyte migration cardiac muscle contraction mitophagy in response to mitochondrial depolarization adaptive immune response inflammatory response phosphatidylinositol 3-kinase signaling phosphorylation innate immune response positive regulation of protein kinase activity cell chemotaxis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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