This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene.
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Protein Aliases: leuserpin 2; phosphatidylinositol 4-kinase; phosphatidylinositol 4-kinase 230; phosphatidylinositol 4-kinase a; Phosphatidylinositol 4-kinase alpha; phosphatidylinositol 4-kinase, catalytic, alpha; phosphatidylinositol 4-kinase, catalytic, alpha polypeptide; phosphatidylinositol 4-kinase, type III, alpha; PI4-kinase alpha; PI4K-alpha; ptdIns-4-kinase alpha; testicular secretory protein Li 35
Gene Aliases: PI4K-ALPHA; pi4K230; PI4KA; PIK4; PIK4CA; PMGYCHA