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Abnova
PIAS1/2 Recombinant Rabbit Monoclonal Antibody
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Product Details
RAB04414
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Androgen receptor-interacting protein 3; AR interacting protein; ARIP3; DAB2-interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; DIP; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein transferase PIAS1; E3 SUMO-protein transferase PIAS2; GBP; Gu-binding protein; Miz1; Msx-interacting zinc finger protein; nuclear protein that binds to nucleolar RNA helicase Gu protein and to p53; PIAS-NY protein; PIAS1/GBP; PIG23; Protein inhibitor of activated STAT protein 1; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2; RNA helicase II-binding protein; unnamed protein product; zinc finger, MIZ-type containing 3; zinc finger, MIZ-type containing 4
Gene Aliases: ARIP3; DDXBP1; DIP; GBP; GU/RH-II; MIZ1; PIAS1; PIAS2; PIASX; SIZ2; ZMIZ3; ZMIZ4
UniProt ID: (Human) O75925, (Human) O75928
Entrez Gene ID: (Human) 8554, (Human) 9063
transcription regulatory region sequence-specific DNA binding
DNA binding
transcription cofactor activity
transcription corepressor activity
protein binding
zinc ion binding
transferase activity
SUMO transferase activity
enzyme binding
protein domain specific binding
ubiquitin protein ligase binding
metal ion binding
SUMO ligase activity
DNA-binding transcription factor binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
protein sumoylation
endoplasmic reticulum unfolded protein response
negative regulation of transcription, DNA-templated
regulation of macromolecule metabolic process
SMAD protein signal transduction
negative regulation of androgen receptor signaling pathway
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair via homologous recombination
DNA double-strand break processing
cellular response to DNA damage stimulus
JAK-STAT cascade
spermatogenesis
visual learning
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein sumoylation
regulation of cell proliferation
negative regulation of apoptotic process
fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of smooth muscle cell differentiation
protein-DNA complex assembly
positive regulation of protein localization to cell periphery
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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