PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
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Protein Aliases: AR interacting protein; DDXBP1; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO protein ligase PIAS1; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein transferase PIAS1; GBP; Gu binding protein; Gu-binding protein; GU/RH II; PIAS1; Protein inhibitor of activated STAT protein 1; protein inhibitor of activated STAT-1; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3; ZMIZ3
Gene Aliases: DDXBP1; GBP; GU/RH-II; PIAS1; ZMIZ3
UniProt ID: (Human) O75925
Entrez Gene ID: (Human) 8554
Molecular Function: ligase