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Abnova
PIAS1 Polyclonal Antibody, MaxPab™
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Product Details
H00008554-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PIAS1 (NP_057250.1, 1 a.a. approximately 651 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MADSAELKQM VMSLRVSELQ VLLGYAGRNK HGRKHELLTK ALHLLKAGCS PAVQMKIKEL YRRRFPQKIM TPADLSIPNV HSSPMPATLS PSTIPQLTYD GHPASSPLLP VSLLGPKHEL ELPHLTSALH PVHPDIKLQK LPFYDLLDEL IKPTSLASDN SQRFRETCFA FALTPQQVQQ ISSSMDISGT KCDFTVQVQL RFCLSETSCP QEDHFPPNLC VKVNTKPCSL PGYLPPTKNG VEPKRPSRPI NITSLVRLST TVPNTIVVSW TAEIGRNYSM AVYLVKQLSS TVLLQRLRAK GIRNPDHSRA LIKEKLTADP DSEIATTSLR VSLLCPLGKM RLTIPCRALT CSHLQCFDAT LYIQMNEKKP TWVCPVCDKK APYEHLIIDG LFMEILKYCT DCDEIQFKED GTWAPMRSKK EVQEVSASYN GVDGCLSSTL EHQVASHHQS SNKNKKVEVI DLTIDSSSDE EEEEPSAKRT CPSLSPTSPL NNKGILSLPH QASPVSRTPS LPAVDTSYIN TSLIQDYRHP FHMTPMPYDL QGLDFFPFLS GDNQHYNTSL LAAAAAAVSD DQDLLHSSRF FPYTSSQMFL DQLSAGGSTS LPTTNGSSSG SNSSLVSSNS LRESHSHTVT NRSSTDTASI FGIIPDIISL D
Target Information
PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AR interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein transferase PIAS1; GBP; Gu binding protein; Gu-binding protein; nuclear protein that binds to nucleolar RNA helicase Gu protein and to p53; PIAS1/GBP; PIG23; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein; unnamed protein product; zinc finger, MIZ-type containing 3
Gene Aliases: DDXBP1; GBP; GU/RH-II; PIAS1; ZMIZ3
UniProt ID: (Human) O75925
Entrez Gene ID: (Human) 8554
transcription regulatory region sequence-specific DNA binding
DNA binding
transcription cofactor activity
transcription corepressor activity
protein binding
zinc ion binding
transferase activity
SUMO transferase activity
enzyme binding
protein domain specific binding
ubiquitin protein ligase binding
metal ion binding
SUMO ligase activity
DNA-binding transcription factor binding
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair via homologous recombination
DNA double-strand break processing
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
JAK-STAT cascade
spermatogenesis
visual learning
protein sumoylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein sumoylation
regulation of cell proliferation
negative regulation of apoptotic process
fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of smooth muscle cell differentiation
regulation of macromolecule metabolic process
protein-DNA complex assembly
positive regulation of protein localization to cell periphery
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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