Invitrogen

PIAS1/PIAS2 Recombinant Rabbit Monoclonal Antibody (8P1D2)

View all (3) PIAS1/PIAS2 antibodies

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Datasheet
Protocols
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Datasheet
Protocols
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PIAS1/PIAS2 Recombinant Rabbit Monoclonal Antibody (8P1D2)

Product Details

MA5-38199

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

8P1D2

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 552-651 of human PIAS1+PIAS2 (O75925)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898116

Product Specific Information

Positive Samples: HepG2, Mouse brain

Immunogen sequence: DNQHYNTSLL AAAAAAVSDD QDLLHSSRFF PYTSSQMFLD QLSAGGSTSL PTTNGSSSGS NSSLVSSNSL RESHSHTVTN RSSTDTASIF GIIPDIISLD

Target Information

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Androgen receptor-interacting protein 3; AR interacting protein; ARIP3; DAB2-interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; DIP; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein transferase PIAS1; E3 SUMO-protein transferase PIAS2; GBP; Gu-binding protein; Miz1; Msx-interacting zinc finger protein; Msx-interacting-zinc finger; Msx-interacting-zinc finger protein; PIAS-NY protein; PIASxalpha6; Protein inhibitor of activated STAT protein 1; Protein inhibitor of activated STAT x; protein inhibitor of activated STAT-1; Protein inhibitor of activated STAT2; RING-type E3 ubiquitin transferase PIAS1; RING-type E3 ubiquitin transferase PIAS2; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3; zinc finger, MIZ-type containing 4

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Gene Aliases: 2900068C24Rik; 6330408K17Rik; AI462206; ARIP3; AU018068; DDXBP1; Dib; DIP; GBP; GU/RH-II; MIZ; MIZ1; PIAS1; PIAS2; PIASX; PIASX-ALPHA; PIASX-BETA; PIASxalpha; PIASxb; PIASxbeta; SIZ2; ZMIZ3; ZMIZ4

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UniProt ID: (Human) O75925, (Human) O75928, (Mouse) O88907, (Rat) Q6AZ28, (Mouse) Q8C5D8

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Entrez Gene ID: (Human) 8554, (Human) 9063, (Mouse) 56469, (Rat) 300772, (Rat) 83422, (Mouse) 17344

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Function(s)
DNA binding transcription coactivator activity transcription corepressor activity protein binding transcription factor binding zinc ion binding ligase activity SUMO transferase activity enzyme binding ubiquitin protein ligase binding androgen receptor binding SUMO ligase activity protein C-terminus binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity protein domain specific binding coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity estrogen receptor binding glucocorticoid receptor binding
Process(es)
transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter spermatogenesis metabolic process response to organic substance protein sumoylation androgen receptor signaling pathway response to testosterone negative regulation of sequence-specific DNA binding transcription factor activity regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of dendrite morphogenesis regulation of androgen receptor signaling pathway negative regulation of androgen receptor signaling pathway G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter JAK-STAT cascade positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein sumoylation regulation of cell proliferation negative regulation of apoptotic process fat cell differentiation positive regulation of smooth muscle cell differentiation protein-DNA complex assembly negative regulation of nucleic acid-templated transcription regulation of interferon-gamma-mediated signaling pathway
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