A suggested positive control is human placenta lysate.
PA5-34514 can be used with blocking peptide PEP-1557.
PIBF1 is synthesized during pregnancy in response to progesterone by T lymphocytes. PIBF1 inhibits arachidonic acid release, controls NK activity, and modifies the cytokine balance exerting an anti-abortive effect. It contains a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an ER membrane retention signal and N-glycosylation and phosphorylation sites. PIBF1 is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF1 is associated with the nucleus and functions as a transcription factor, whereas secretion of shorter forms which may act as cytokines is induced by activation of the cell.
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Protein Aliases: Centrosomal protein of 90 kDa; CEP90; PIBF; PIBF1; Progesterone immunomodulatory binding factor 1; progesterone-induced blocking factor 1; Progesterone-induced-blocking factor 1
Gene Aliases: C13orf24; CEP90; PIBF; PIBF1; RGD1305077
UniProt ID: (Human) Q8WXW3