PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.
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Protein Aliases: MGC15204; OTTHUMP00000028509; PRKCA-binding protein; Protein interacting with C kinase 1; protein kinase C, alpha binding protein; Protein kinase C-alpha-binding protein; protein that interacts with C kinase 1
Gene Aliases: PICK; PICK1; PRKCABP
Molecular Function: vesicle coat protein