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|Tested species reactivity||Mouse, Rat|
|Host / Isotype||Chicken / IgY|
|Immunogen||Synthetic peptide RGATGPTDKGGSWCDS corresponding to the C-terminus of rat PICK1.|
|Purification||Antigen affinity chromatography|
|Storage buffer||BBS with 1% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PICK1 contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. PICK1 has been shown to interact with multiple glutamate receptor subtypes, glutamate transporter subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. PICK1 has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for PICK1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
alpha binding protein; PRKCA-binding protein; Prkcabp; protein interacting with C kinase 1; protein kinase C; protein kinase C, alpha binding protein; protein kinase C-alpha-binding protein; protein that interacts with C kinase 1