This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human PIG3/TP53I3.
The p53 protein (393 AS, phosphoprotein) is a transcription factor, whose activity is regulated by phosphorylation. The normal function of p53 is to effect cell cycle arrest at the G1- and G2-checkpoints in response to DNA damage. The current model postulates that p53 senses DNA damage and arrests the cell cycle to allow DNA repair to take place. If repair is not successful, p53 initiates programmed cell death. In normal cells the p53 level is low. In response to DNA damage or other cellular stress signals the checkpoint function is executed by accumulation of p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: p53 Inducible Gene 3; p53-induced gene 3 protein; quinone oxidoreductase homolog; Quinone oxidoreductase PIG3; Tumor protein p53-inducible protein 3
Gene Aliases: PIG3; TP53I3
UniProt ID: (Human) Q53FA7
Entrez Gene ID: (Human) 9540