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Immunogen sequence: FADVSSVLTN KLLTVSLCDT NHIICVSYTS KENTVLRAAL NPEIVSVIPN AVDPTDFTPD PFRRHDSITI VVVSRLVYRK GIDLLSGIIP ELCQKYPDLN FIIGGEGPKR II
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: class A GlcNAc-inositol phospholipid assembly protein; GLCNAC-PI synthesis protein; GPI anchor biosynthesis; phosphatidylinositol glycan anchor biosynthesis, class A; Phosphatidylinositol N-acetylglucosaminyltransferase subunit A; Phosphatidylinositol-glycan biosynthesis class A protein; phosphatidylinositol-glycan biosynthesis, class A protein; PIG-A
Gene Aliases: GPI3; MCAHS2; PIG-A; PIGA; PNH1
UniProt ID: (Human) P37287
Entrez Gene ID: (Human) 5277
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