PIGM encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. PIGM encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum.
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Protein Aliases: dol-P-Man dependent GPI mannosyltransferase; DPM:GlcN-(acyl-)PI mannosyltransferase; GPI mannosyltransferase 1; GPI mannosyltransferase I; GPI-MT-I; phosphatidylinositol glycan anchor biosynthesis, class M; phosphatidylinositol glycan, class M; Phosphatidylinositol-glycan biosynthesis class M protein; PIG-M; PIG-M mannosyltransferase; PIG-M mRNA for mannosyltransferase
Gene Aliases: 4933437L05Rik; AI644422; AV302080; C920011G20Rik; GPI-MT-I; PIGM