The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors.
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Protein Aliases: dol-P-Man dependent GPI mannosyltransferase; GPI mannosyltransferase 4; GPI mannosyltransferase IV; GPI-MT-IV; hSMP3; phosphatidylinositol glycan anchor biosynthesis, class Z; phosphatidylinositol glycan, class Z; phosphatidylinositol glycan, class Z-like 1; Phosphatidylinositol-glycan biosynthesis class Z protein; PIG-Z; SMP3 homolog; SMP3 mannosyltransferase
Gene Aliases: F630022B06Rik; GPI-MT-IV; PIG-Z; PIGZ; RGD1307107; SMP3