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Invitrogen
PIK3C2G Polyclonal Antibody
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Product Details
PA5-99834
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PIK3C2G(Accession O75747), corresponding to amino acid residues S1362-I1412.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PIK3C2G.
Target Information
PIK3C2G lipid kinase belongs to the phosphoinositide 3-kinase (PI3K) family which play major roles in signaling pathways and are involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. PIK3C2G contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases that act as calcium-dependent phospholipid binding motifs which mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The N-terminal region of PIK3C2G and the C-terminal C2 domain are required for enzymatic activity. The PI 3-kinase C2gamma gene encodes a 1,050 amino acid polypeptide with 36% identity to human PI 3-kinase C2alpha. Research indicates that PI 3-kinase C2gamma can block the growth of human colon cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma; Phosphoinositide 3-kinase-C2-gamma; phosphoinositide-3-kinase, class 2, gamma polypeptide; PI 3-kinase C2gamma; PI3K-C2-gamma; PI3KC2gamma; PTDINS-3-kinase C2 gamma; ptdIns-3-kinase C2 subunit gamma
Gene Aliases: C80387; PI3K-C2-gamma; PI3K-C2GAMMA; PIK3C2G
UniProt ID: (Human) O75747, (Mouse) O70167
Entrez Gene ID: (Human) 5288, (Mouse) 18705
nucleotide binding
ATP binding
kinase activity
1-phosphatidylinositol-3-kinase activity
transferase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
phosphatidylinositol binding
phosphatidylinositol kinase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
kinase
lipid metabolic process
chemotaxis
cell migration
phosphatidylinositol-3-phosphate biosynthetic process
protein kinase B signaling
modulation by host of viral process
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
adaptive immune response
protein phosphorylation
inflammatory response
phosphatidylinositol 3-kinase signaling
phosphorylation
platelet activation
innate immune response
cell chemotaxis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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