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Invitrogen
PIK3CA Polyclonal Antibody
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Product Details
PA5-87398
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 401-600 of human PIK3CA (NP_0062092)
Conjugate
Form
Liquid
Concentration
0.64 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HeLa
Immunogen sequence: RLCLSICSVK GRKGAKEEHC PLAWGNINLF DYTDTLVSGK MALNLWPVPH GLEDLLNPIG VTGSNPNKET PCLELEFDWF SSVVKFPDMS VIEEHANWSV SREAGFSYSH AGLSNRLARD NELRENDKEQ LKAISTRDPL SEITEQEKDF LWSHRHYCVT IPEILPKLLL SVKWNSRDEV AQMYCLVKDW PPIKPEQAME
Target Information
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2.7.1.153; EC:2.7.11.1; GRB1; MGC142161; MGC142163; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K alpha; PI3K-alpha; PI3Kalpha; pi3kca; PIK3R1; pk3ca; ptdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA
Gene Aliases: 6330412C24Rik; caPI3K; CLOVE; CWS5; MCAP; MCM; MCMTC; p110; p110-alpha; p110alpha; PI3K; PI3K-alpha; PIK3CA
UniProt ID: (Human) P42336, (Mouse) P42337, (Rat) A0A0G2K344
Entrez Gene ID: (Human) 5290, (Mouse) 18706, (Rat) 170911
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
1-phosphatidylinositol-3-kinase activity
protein kinase activator activity
phosphatidylinositol 3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
insulin receptor substrate binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
kinase
angiogenesis
liver development
vasculature development
glucose metabolic process
protein phosphorylation
phosphatidylinositol biosynthetic process
epidermal growth factor receptor signaling pathway
regulation of gene expression
regulation of phosphatidylinositol 3-kinase signaling
platelet activation
T cell costimulation
activation of protein kinase activity
positive regulation of peptidyl-serine phosphorylation
phosphatidylinositol-3-phosphate biosynthetic process
insulin receptor signaling pathway via phosphatidylinositol 3-kinase
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
ERBB2 signaling pathway
regulation of multicellular organism growth
regulation of cellular respiration
protein kinase B signaling
negative regulation of neuron apoptotic process
endothelial cell migration
hypomethylation of CpG island
phosphatidylinositol phosphorylation
vascular endothelial growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
T cell receptor signaling pathway
leukocyte migration
cardiac muscle contraction
adipose tissue development
cellular response to glucose stimulus
energy homeostasis
mitophagy in response to mitochondrial depolarization
negative regulation of fibroblast apoptotic process
regulation of genetic imprinting
negative regulation of anoikis
adaptive immune response
inflammatory response
phosphatidylinositol 3-kinase signaling
phosphorylation
innate immune response
positive regulation of protein kinase activity
cell chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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