Invitrogen

PIK3CB Polyclonal Antibody

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PIK3CB Polyclonal Antibody

Product Details

PA5-120062

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 410-600 of human PI3 Kinase p110 beta (NP_0062101)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.69 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913634

Product Specific Information

Positive test controls include: MCF7, Mouse brain. The target is usually found in the following locations: Cytoplasm, Nucleus.

Immunogen sequence: KVKTKKSTKT INPSKYQTIR KAGKVHYPVA WVNTMVFDFK GQLRTGDIIL HSWSSFPDEL EEMLNPMGTV QTNPYTENAT ALHVKFPENK KQPYYYPPFD KIIEKAAEIA SSDSANVSSR GGKKFLPVLK EILDRDPLSQ LCENEMDLIW TLRQDCREIF PQSLPKLLLS IKWNKLEDVA QLQALLQIWP K

Target Information

PIK3CB (phosphatyidylinositol 4,5-biphosphate 3-kinase catalyic subunit beta isoform) is a phosphoinositide-3-kinase that phosphorylates PtdIns (phosphatidylinositol), PtdIns4P (phosphatidylinositol 4-phosphate), and PtdIns(4,5)P2 (phosphatidylinositol 4,5-biphosphate) to generate phosphatidylinositol 3,4,5-triphosphate (PIP3). PIP3 plays a key role in recruiting PH domain-containing proteins to the membrane and activating signaling cascades involved in cell growth, survival, proliferation, motility, and morphology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: catalytic phosphatidylinositol 3-kinase beta; p110beta; phosphatidylinositol 3-kinase catalytic subunit beta isoform; phosphatidylinositol 3-kinase, catalytic subunit, beta isoform; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K-beta; PI3Kbeta; pi3kcb; PtdIns-3-kinase p110; ptdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; Serine/threonine protein kinase PIK3CB

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Gene Aliases: 1110001J02Rik; AI447572; P110BETA; PI3K; PI3KBETA; PIK3C1; PIK3CB

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UniProt ID: (Human) P42338, (Mouse) Q8BTI9, (Rat) Q9Z1L0

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Entrez Gene ID: (Human) 5291, (Mouse) 74769, (Rat) 85243

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Function(s)
protein binding ATP binding 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups phosphotransferase activity, alcohol group as acceptor kinase
Process(es)
activation of MAPK activity endothelial cell proliferation regulation of cell-matrix adhesion phosphatidylinositol biosynthetic process cellular calcium ion homeostasis autophagy chemotaxis homophilic cell adhesion via plasma membrane adhesion molecules signal transduction transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway positive regulation of autophagy positive regulation of gene expression phosphatidylinositol 3-kinase signaling regulation of phosphatidylinositol 3-kinase signaling cell migration platelet activation phosphatidylinositol-3-phosphate biosynthetic process Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis embryonic cleavage phosphatidylinositol phosphorylation vascular endothelial growth factor receptor signaling pathway phosphatidylinositol-mediated signaling T cell receptor signaling pathway leukocyte migration angiogenesis involved in wound healing platelet aggregation regulation of clathrin-mediated endocytosis adaptive immune response protein phosphorylation endocytosis inflammatory response cell adhesion response to wounding phosphorylation innate immune response cell chemotaxis
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