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Invitrogen
PIK3CB Polyclonal Antibody
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FIGURE: 1 / 4
PIK3CB Antibody (PA5-15249) in IHC (P)
Immunohistochemistry analysis of PIK3CB in formalin fixed and paraffin embedded human pancreas tissue. Samples were incubated with PIK3CB polyclonal antibody (Product # PA5-15249) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-15249
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 124-154 amino acids from the N-terminal region of human PIK3CB
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PIK3CB (phosphatyidylinositol 4,5-biphosphate 3-kinase catalyic subunit beta isoform) is a phosphoinositide-3-kinase that phosphorylates PtdIns (phosphatidylinositol), PtdIns4P (phosphatidylinositol 4-phosphate), and PtdIns(4,5)P2 (phosphatidylinositol 4,5-biphosphate) to generate phosphatidylinositol 3,4,5-triphosphate (PIP3). PIP3 plays a key role in recruiting PH domain-containing proteins to the membrane and activating signaling cascades involved in cell growth, survival, proliferation, motility, and morphology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 110 kda catalytic subunit; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K-beta; pi3kcb; PtdIns-3-kinase p110; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB; unnamed protein product
Gene Aliases: P110BETA; PI3K; PI3KBETA; PIK3C1
UniProt ID: (Human) P42338
Entrez Gene ID: (Human) 5291
regulation of cell-matrix adhesion
leukocyte mediated immunity
response to ischemia
sphingosine-1-phosphate signaling pathway
chemotaxis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of autophagy
positive regulation of endothelial cell migration
positive regulation of gene expression
cell migration
regulation of cell adhesion
platelet activation
positive regulation of neutrophil apoptotic process
positive regulation of Rac protein signal transduction
phosphatidylinositol-3-phosphate biosynthetic process
natural killer cell mediated cytotoxicity
negative regulation of MAPK cascade
protein kinase B signaling
innate immune response
positive regulation of nitric oxide biosynthetic process
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
negative regulation of protein kinase B signaling
platelet aggregation
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of sprouting angiogenesis
regulation of clathrin-mediated endocytosis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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