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Proteintech

PIK3CG Polyclonal Antibody

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PIK3CG Polyclonal Antibody

Product Details

31229-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PIK3CG fusion protein Ag34951
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: VVLDTPPDPA LDEVRKEEWP LVDDCTGVTG YHEQLTIHGK DHESVFTVSL WDCDRKFRVK IRGIDIPVLP RNTDLTVFVE ANIQHGQQVL CQRRTSPKPF TEEVLWNVWL EFSIKIKDLP KGALLNLQIY CGKAPALSSK ASAESPSSES KGKVQLLYYV NLLLIDHRFL LRRGEYVL

Target Information

PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member, which along with the class IA family members, generates the important second messenger PIP2. However, unlike the class IA enzymes which signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-phosphatidylinositol 3-kinase; catalytic subunit; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphoinositide-3-kinase catalytic gamma polypeptide; phosphoinositide-3-kinase gamma catalytic subunit; PI3-kinase subunit gamma; PI3K-gamma; pi3kcg; ptdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma; Serine/threonine protein kinase PIK3CG; unnamed protein product

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Gene Aliases: 5830428L06Rik; IMD97; p110gamma; p120-PI3K; PI3CG; PI3K; Pi3kg1; PI3Kgamma; PIK3; PIK3CG

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UniProt ID: (Human) P48736, (Mouse) Q9JHG7

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Entrez Gene ID: (Human) 5294, (Mouse) 30955

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity 1-phosphatidylinositol-3-kinase activity transferase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity identical protein binding ephrin receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein serine kinase activity transferase activity, transferring phosphorus-containing groups phosphotransferase activity, alcohol group as acceptor kinase
Process(es)
angiogenesis positive regulation of cytokine production adaptive immune response immune system process dendritic cell chemotaxis positive regulation of acute inflammatory response respiratory burst involved in defense response sphingosine-1-phosphate signaling pathway lipid metabolic process endocytosis chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of endothelial cell migration T cell chemotaxis negative regulation of triglyceride catabolic process cell migration neutrophil chemotaxis secretory granule localization regulation of cell adhesion mediated by integrin positive regulation of Rac protein signal transduction natural killer cell chemotaxis phosphatidylinositol-3-phosphate biosynthetic process T cell proliferation T cell activation mast cell degranulation positive regulation of MAP kinase activity protein kinase B signaling innate immune response regulation of angiogenesis phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling positive regulation of protein kinase B signaling negative regulation of cardiac muscle contraction platelet aggregation cellular response to cAMP neutrophil extravasation hepatocyte apoptotic process regulation of calcium ion transmembrane transport negative regulation of fibroblast apoptotic process regulation of protein phosphorylation protein phosphorylation phosphatidylinositol 3-kinase signaling phosphorylation platelet activation positive regulation of catalytic activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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