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Invitrogen
PIK3R2 Polyclonal Antibody
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FIGURE: 1 / 2
PIK3R2 Antibody (PA5-101022) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded PI3K p85 beta in mouse liver tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with PI3K p85 beta polyclonal antibody (Product # PA5-101022) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-101022
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PIK3R2(Accession O00459), corresponding to amino acid residues Y577-I627.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PI 3 Kinase p85 beta.
Target Information
Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulartory subunit polypeptide 2; Phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphoinositide-3-kinase regulatory subunit beta; phosphoinositide-3-kinase, regulatory subunit 2 (beta); PI3-kinase p85 subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K; PI3K regulatory subunit beta; ptdIns-3-kinase p85-beta; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta
Gene Aliases: MPPH; MPPH1; p85; p85-BETA; P85B; p85beta; PIK3R2
UniProt ID: (Human) O00459, (Mouse) O08908
Entrez Gene ID: (Human) 5296, (Mouse) 18709, (Rat) 29741
GTPase activator activity
protein binding
1-phosphatidylinositol-3-kinase activity
protein phosphatase binding
receptor tyrosine kinase binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
1-phosphatidylinositol-3-kinase regulator activity
protein heterodimerization activity
transcription factor binding
phosphatidylinositol 3-kinase regulator activity
phosphatidylinositol 3-kinase regulatory subunit binding
kinase modulator
cellular glucose homeostasis
phosphatidylinositol biosynthetic process
insulin receptor signaling pathway
regulation of autophagy
phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
protein transport
cellular response to insulin stimulus
response to endoplasmic reticulum stress
phosphatidylinositol-3-phosphate biosynthetic process
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of transcription factor import into nucleus
positive regulation of GTPase activity
regulation of phosphatidylinositol 3-kinase activity
positive regulation of transcription from RNA polymerase II promoter
phosphatidylinositol phosphorylation
vascular endothelial growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
T cell receptor signaling pathway
leukocyte migration
regulation of small GTPase mediated signal transduction
positive regulation of glucose import in response to insulin stimulus
transport
signal transduction
regulation of actin filament polymerization
regulation of phosphorylation
positive regulation of cell adhesion
regulation of stress fiber assembly
regulation of establishment of protein localization to plasma membrane
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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