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Invitrogen
PIK3R6 Polyclonal Antibody
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Product Details
PA5-54689
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PIK3R6. Recombinant protein control fragment (Product #RP-93428).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PAAPVTDHTC LNVNVTEVVK SSNLAGKSFS TVTNTFRTNN IQIQSRDQRL LTLSLDKDDQ RTFRDVVRFE VAPCPEPCSG AQKSKAPWLN LHGQQEVEAI KAKPKP
Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 67%.
Target Information
p87PIKAP (p87 PI3K adapter protein), also known as PIK3R6 (phosphoinositide-3-kinase, regulatory subunit 6), p84 or HsT41028, is a 754 amino acid cytoplasmic protein that functions as a regulatory subunit of the PI 3-kinase p110 complex. Expressed in heart, dendritic cells, macrophages and neutrophils, p87PIKAP drives PI 3-kinase p110 activation, interacts with PDE3B and is thought to cause the two proteins to form a scaffolding interaction. The gene encoding p87PIKAP maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1, 200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: p84 PI3K adapter protein; p84 PIKAP; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein; p87 PI3K adapter protein; p87PIKAP; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; Phosphoinositide 3-kinase regulatory subunit 6; phosphoinositide-3-kinase, regulatory subunit 6; PI3Kgamma adapter protein of 87 kDa
Gene Aliases: C17orf38; HsT41028; p84 PIKAP; p87(PIKAP); p87PIKAP; PIK3R6
UniProt ID: (Human) Q5UE93
Entrez Gene ID: (Human) 146850
angiogenesis
phosphatidylinositol biosynthetic process
G-protein coupled receptor signaling pathway
platelet activation
regulation of natural killer cell mediated cytotoxicity
positive regulation of MAP kinase activity
regulation of phosphatidylinositol 3-kinase activity
positive regulation of T cell differentiation
positive regulation of angiogenesis
phosphatidylinositol phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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