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PIM3 serine/threonine kinase or PIM-3 oncogene belongs to a family of protooncogenes. PIM3 is expressed in hepatocellular carcinoma development and plays a main role in the proliferation of human hepatoma cell lines. PIM3 also expressed in human pancreatic cancer cells and phosphorylates BAD to block Bad-mediated apoptosis in human pancreatic cancer cell lines. PIM3 is widely expressed, with the exception of no expression observed in colon, thymus, and small intestine.
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Protein Aliases: KID-1/kinase induced by depolarization; pim-3 oncogene; serine/threonine kinase Pim-3; Serine/threonine-protein kinase pim-3
Gene Aliases: BC026639; Kid1; pim-3; PIM3
Molecular Function: non-receptor serine/threonine protein kinase