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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide: Y(258) R K S K R G P K Q L A P H P N I(274)|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4515 detects PINK1 in human samples.
PA1-4515 has been successfully used in Western blotting procedures. By Western blot, this antibody detects a ~64 kDa protein representing PINK1 in transfected HEK293T cells.
PA1-4515 immunizing peptide corresponds to amino acid residues 258-274 of human PINK1.
Mutations in the PTEN-induced kinase (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
PARK6; Phosphatase and Tensin Homolog; PINK1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine kinase PINK1 mitochondrial
BRPK; PARK6; PINK1