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Invitrogen

PINK1 Polyclonal Antibody

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View all (46) PINK1 antibodies

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PINK1 Polyclonal Antibody

Product Details

PA5-13402

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 118-147 amino acids from the N-terminal region of human PINK1 (PARK6)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

800 µg

Purification

Size-exclusion - Dialysis, Ammonium sulfate precipitation

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2252385

Target Information

PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BRPK; FLJ27236; PINK 1; PINK-1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial; unnamed protein product

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Gene Aliases: BRPK; PARK6; PINK1

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UniProt ID: (Human) Q9BXM7

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Entrez Gene ID: (Human) 65018

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Function(s)
nucleotide binding magnesium ion binding protease binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity peptidase activator activity transferase activity kinase binding ubiquitin protein ligase binding protein kinase B binding macromolecular complex binding metal ion binding C3HC4-type RING finger domain binding protein serine kinase activity
Process(es)
mitophagy mitophagy regulation of oxidative phosphorylation response to ischemia protein phosphorylation ubiquitin-dependent protein catabolic process autophagy response to stress response to oxidative stress mitochondrion organization regulation of hydrogen peroxide metabolic process negative regulation of gene expression regulation of mitochondrion organization dopamine secretion macroautophagy positive regulation of macroautophagy negative regulation of macroautophagy protein ubiquitination respiratory electron transport chain hemopoiesis positive regulation of cell migration regulation of protein ubiquitination positive regulation of protein ubiquitination positive regulation of synaptic transmission, dopaminergic positive regulation of dopamine secretion positive regulation of catecholamine secretion cellular response to oxidative stress intracellular signal transduction TORC2 signaling regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of translation positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade catecholamine secretion protein stabilization establishment of localization in cell regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling regulation of proteasomal protein catabolic process cellular response to hypoxia establishment of protein localization to mitochondrion maintenance of protein location in mitochondrion positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria negative regulation of mitochondrial fission cellular response to toxic substance mitochondrion to lysosome transport regulation of cellular response to oxidative stress negative regulation of macromitophagy regulation of synaptic vesicle transport negative regulation of autophagosome assembly positive regulation of mitochondrial electron transport, NADH to ubiquinone regulation of mitophagy regulation of protein targeting to mitochondrion negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide positive regulation of cristae formation positive regulation of protein targeting to mitochondrion positive regulation of free ubiquitin chain polymerization cellular response to hydrogen sulfide positive regulation of type 2 mitophagy regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process positive regulation of ATP biosynthetic process negative regulation of intrinsic apoptotic signaling pathway
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