Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Human (99%), Bovine (80%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. [UniProt]
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 67-11-3 protein; FLJ20565; hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; MGC8850; PIN2 interacting protein 1; pin2-interact; PIN2-interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; Protein 67-11-3; TRF1-interacting protein 1
Gene Aliases: LPTL; LPTS; PINX1
UniProt ID: (Human) Q96BK5
Entrez Gene ID: (Human) 54984