Phosphatidylserine decarboxylases catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits.
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Protein Aliases: DKFZp566G2246; phosphatidylserine decarboxylase; Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain; phosphatidylserine decarboxylase proenzyme; Phosphatidylserine decarboxylase proenzyme, mitochondrial
Gene Aliases: 9030221M09Rik; DJ858B16; dJ858B16.2; PISD; PSD; PSDC; PSSC
Molecular Function: decarboxylase