Recommended positive controls: HepG2.
Predicted reactivity: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 86%.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans . PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.
Protein Aliases: GHF-1; Growth hormone factor 1; PIT-1; Pituitary-specific positive transcription factor 1; POU domain, class 1, transcription factor 1
Gene Aliases: CPHD1; GHF-1; GHF1; Pit-1; PIT1; POU1F1; POU1F1a
UniProt ID: (Human) P28069
Entrez Gene ID: (Human) 5449