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|Tested species reactivity||Dog, Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide region of human POU1F1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 2% sucrose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||4-8 ug/ml|
|Western Blot (WB)||1-10 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24436 detects PIT1/POU1F1 in human, mouse, rat, and canine samples.
PA1-24436 has been successfully used in Western blot and immunohistochemistry (paraffin) procedures.
The PA1-24436 immunogen is a synthetic peptide region of human POU1F1.
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans . PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
GHF-1; growth hormone factor 1; homeodomain protein for Growth Hormone (GH); pit-1; Pituary specific transcription factor 1 (growth hormone factor 1); pituitary specific transcription factor 1; pituitary specific transcription factor 1, related sequence 1; pituitary-specific positive transcription factor 1; pituitary-specific positive transcription factor 1 variant w; POU domain, class 1, transcription factor 1; POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1); POU1F1
CPHD1; dw; dwarf; GHF-1; GHF1; GHF1A; Hmp1; PIT-1; PIT1; Pit1-rs1; PIT1Z; POU1F1; POU1F1a