PA1-24436 detects PIT1/POU1F1 in human, mouse, rat, and canine samples.
PA1-24436 has been successfully used in Western blot and immunohistochemistry (paraffin) procedures.
The PA1-24436 immunogen is a synthetic peptide region of human POU1F1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans . PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GHF-1; Growth hormone factor 1; homeodomain protein for Growth Hormone (GH); PIT-1; Pituary specific transcription factor 1 (growth hormone factor 1); pituitary specific transcription factor 1; pituitary specific transcription factor 1, related sequence 1; Pituitary-specific positive transcription factor 1; pituitary-specific positive transcription factor 1 variant w; POU domain, class 1, transcription factor 1; POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1); POU1F1
Gene Aliases: CPHD1; dw; dwarf; GHF-1; GHF1; GHF1A; Hmp1; PIT-1; PIT1; Pit1-rs1; PIT1Z; POU1F1; POU1F1a