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FIGURE: 1 / 1
Immunogen sequence: MDSPEIRELE KFANEFKVRR IKLGYTQTNV GEALAAVHGS EFSQTTICRF ENLQLSFKNA CKLKAILSKW LEEAEQVGAL YNEKVGANER KRKRRTTISI AAKDALERHF GEQNKPSSQE IMRMAEELNL EKEVVRVWFC NRRQREKRVK
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GHF-1; Growth hormone factor 1; PIT-1; Pituitary-specific positive transcription factor 1; POU domain, class 1, transcription factor 1
Gene Aliases: CPHD1; GHF-1; GHF1; Pit-1; PIT1; POU1F1; POU1F1a
UniProt ID: (Human) P28069
Entrez Gene ID: (Human) 5449
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