Invitrogen

PITX2 Polyclonal Antibody

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Product Details

PA5-85551

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000-1:20,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the N-terminus region of human PITX2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792691

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (93%).

Positive Control: human PITX2-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: all1-responsive gene 1; ALL1-responsive protein ARP1; Homeobox protein PITX2; paired-like homeodomain 2; Paired-like homeodomain transcription factor 2; Pituitary homeobox 2; RIEG bicoid-related homeobox transcription factor; rieg bicoid-related homeobox transcription factor 1; S a 1 glycoprotein; S a1glycoprotein; S alpha 1 glycoprotein; S α 1 glycoprotein; S α1glycoprotein; Solurshin

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Gene Aliases: ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2; Otlx2; PITX2; PTX2; RGS; RIEG; RIEG1; RS

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UniProt ID: (Human) Q99697

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Entrez Gene ID: (Human) 5308

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding chromatin DNA binding homeodomain transcription factor
Process(es)
patterning of blood vessels vasculogenesis in utero embryonic development neuron migration extraocular skeletal muscle development atrioventricular valve development cardiac neural crest cell migration involved in outflow tract morphogenesis pulmonary myocardium development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter determination of left/right symmetry myoblast fusion male gonad development female gonad development response to hormone Wnt signaling pathway subthalamic nucleus development hypothalamus cell migration regulation of cell migration embryonic camera-type eye development response to vitamin A embryonic hindlimb morphogenesis hair cell differentiation vascular smooth muscle cell differentiation deltoid tuberosity development odontogenesis of dentin-containing tooth odontogenesis camera-type eye development positive regulation of DNA binding positive regulation of transcription from RNA polymerase II promoter spleen development embryonic digestive tract morphogenesis atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle cell development somatotropin secreting cell differentiation prolactin secreting cell differentiation ventricular septum morphogenesis left lung morphogenesis pulmonary vein morphogenesis superior vena cava morphogenesis endodermal digestive tract morphogenesis iris morphogenesis cell proliferation involved in outflow tract morphogenesis left/right axis specification positive regulation of myoblast proliferation
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