Product References
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.
Nature communications
Schmidt S,Luecken MD,Trümbach D,Hembach S,Niedermeier KM,Wenck N,Pflügler K,Stautner C,Böttcher A,Lickert H,Ramirez-Suastegui C,Ahmad R,Ziller MJ,Fitzgerald JC,Ruf V,van de Berg WDJ,Jonker AJ,Gasser T,Winner B,Winkler J,Vogt Weisenhorn DM,Giesert F,Theis FJ,Wurst W
38-2850 was used in Immunocytochemistry-immunofluorescence to analyze human neural precursor cells (hNPCs) from sporadic PD (sPD) patients.
Tue Aug 16 00:00:00 EDT 2022
Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.
Frontiers in cell and developmental biology
Nouri P,Götz S,Rauser B,Irmler M,Peng C,Trümbach D,Kempny C,Lechermeier CG,Bryniok A,Dlugos A,Euchner E,Beckers J,Brodski C,Klümper C,Wurst W,Prakash N
Published figure using PITX3 polyclonal antibody (Product # 38-2850) in Immunohistochemistry
Tue Nov 17 00:00:00 EST 2020
Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.
Frontiers in cell and developmental biology
Nouri P,Götz S,Rauser B,Irmler M,Peng C,Trümbach D,Kempny C,Lechermeier CG,Bryniok A,Dlugos A,Euchner E,Beckers J,Brodski C,Klümper C,Wurst W,Prakash N
Published figure using PITX3 polyclonal antibody (Product # 38-2850) in Immunohistochemistry
Tue Nov 17 00:00:00 EST 2020
Definition of a critical spatiotemporal window within which primary cilia control midbrain dopaminergic neurogenesis.
Neurogenesis (Austin, Tex.)
Gazea M,Tasouri E,Heigl T,Bosch V,Tucker KL,Blaess S
Published figure using PITX3 polyclonal antibody (Product # 38-2850) in Immunofluorescence
Thu Oct 01 00:00:00 EDT 2020
Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids.
Stem cell reports
Kim H,Park HJ,Choi H,Chang Y,Park H,Shin J,Kim J,Lengner CJ,Lee YK,Kim J
38-2850 was used in Western Blotting to study the pathogenic mechanisms associated with Parkinson's disease-associated LRRK2 mutation.
Tue Mar 05 00:00:00 EST 2019
BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jovanovic VM,Salti A,Tilleman H,Zega K,Jukic MM,Zou H,Friedel RH,Prakash N,Blaess S,Edenhofer F,Brodski C
38-2850 was used in Immunohistochemistry-immunofluorescence to identify BMP/SMAD signalling as a novel critical pathway orchestrating essential steps of mammalian midbrain dopaminergic neurogenesis in vivo that balances progenitor proliferation and differentiation.
Wed Feb 14 00:00:00 EST 2018
A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons.
Development (Cambridge, England)
Nouri N,Awatramani R
38-2850 was used in Immunohistochemistry to identify a novel boundary subdividing the mesodiencephalic floor plate into two microdomains, defined by engrailed 1 and developing brain homeobox 1.
Wed Mar 01 00:00:00 EST 2017
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease.
The EMBO journal
Villaescusa JC,Li B,Toledo EM,Rivetti di Val Cervo P,Yang S,Stott SR,Kaiser K,Islam S,Gyllborg D,Laguna-Goya R,Landreh M,Lönnerberg P,Falk A,Bergman T,Barker RA,Linnarsson S,Selleri L,Arenas E
38-2850 was used in Immunofluorescence in immunohistochemistry on frozen tissues to study a novel transcriptional network controlled by pre-B-cell leukaemia homeobox 1, required for midbrain dopaminergic neuron specification and survival.
Thu Sep 15 00:00:00 EDT 2016
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.
Developmental biology
Gazea M,Tasouri E,Tolve M,Bosch V,Kabanova A,Gojak C,Kurtulmus B,Novikov O,Spatz J,Pereira G,Hübner W,Brodski C,Tucker KL,Blaess S
38-2850 was used in immunohistochemistry to characterize sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain by primary cilia
Fri Jan 01 00:00:00 EST 2016
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons.
Nature communications
Jiang H,Xu Z,Zhong P,Ren Y,Liang G,Schilling HA,Hu Z,Zhang Y,Wang X,Chen S,Yan Z,Feng J
Published figure using PITX3 polyclonal antibody (Product # 38-2850) in Immunocytochemistry
Mon Dec 07 00:00:00 EST 2015
Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fukusumi Y,Meier F,Götz S,Matheus F,Irmler M,Beckervordersandforth R,Faus-Kessler T,Minina E,Rauser B,Zhang J,Arenas E,Andersson E,Niehrs C,Beckers J,Simeone A,Wurst W,Prakash N
Published figure using PITX3 polyclonal antibody (Product # 38-2850) in Immunofluorescence
Wed Sep 30 00:00:00 EDT 2015
Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Stott SR,Metzakopian E,Lin W,Kaestner KH,Hen R,Ang SL
38-2850 was used in Immunohistochemistry to demonstrate a later role for Foxa genes in regulating the maintenance of dopaminergic phenotype in mesodiencephalic dopaminergic neurons.
Wed May 01 00:00:00 EDT 2013
Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease.
Neurobiology of aging
Reyes S,Fu Y,Double KL,Cottam V,Thompson LH,Kirik D,Paxinos G,Watson C,Cooper HM,Halliday GM
38-2850 was used in immunohistochemistry to determine the localization of Pitx3, Otx2, and DCC in the human brain.
Fri Mar 01 00:00:00 EST 2013
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis.
Nature chemical biology
Theofilopoulos S,Wang Y,Kitambi SS,Sacchetti P,Sousa KM,Bodin K,Kirk J,Saltó C,Gustafsson M,Toledo EM,Karu K,Gustafsson JÅ,Steffensen KR,Ernfors P,Sjövall J,Griffiths WJ,Arenas E
38-2850 was used in immunocytochemistry to identify regulators of neurogenesis and neuronal survival.
Fri Feb 01 00:00:00 EST 2013
Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Peng C,Aron L,Klein R,Li M,Wurst W,Prakash N,Le W
Wed Sep 07 00:00:00 EDT 2011
Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Peng C,Aron L,Klein R,Li M,Wurst W,Prakash N,Le W
Wed Sep 07 00:00:00 EDT 2011
Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yan CH,Levesque M,Claxton S,Johnson RL,Ang SL
Wed Aug 31 00:00:00 EDT 2011
Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse.
Neurobiology of disease
Panayotis N,Pratte M,Borges-Correia A,Ghata A,Villard L,Roux JC
38-2850 was used in immunohistochemistry - frozen section to investigate the role of Mecp2 in central dopaminergic neurons using a Rett syndrome mouse model
Tue Feb 01 00:00:00 EST 2011
Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tang M,Villaescusa JC,Luo SX,Guitarte C,Lei S,Miyamoto Y,Taketo MM,Arenas E,Huang EJ
Wed Jul 07 00:00:00 EDT 2010
Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development.
Developmental dynamics : an official publication of the American Association of Anatomists
Li Y,Piatigorsky J
Published figure using PITX3 polyclonal antibody (Product # 38-2850) in Immunohistochemistry
Tue Sep 01 00:00:00 EDT 2009
In-vitro analysis of Pitx3 in mesodiencephalic dopaminergic neuron maturation.
The European journal of neuroscience
Papanikolaou T,Amano T,Lennington J,Sink K,Farrar AM,Salamone J,Yang X,Conover JC
38-2850 was used in Immunocytochemistry-immunofluorescence to assess the role of Pitx3 in the specification and final maturation of dopaminergic neurons by using Pitx3-deficient embryonic stem cells in an in-vitro differentiation culture system.
Mon Jun 01 00:00:00 EDT 2009
Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Roybon L,Hjalt T,Christophersen NS,Li JY,Brundin P
38-2850 was used in immunocytochemistry to elucidate how to induce controlled differentiation of neural stem cells
Wed Apr 02 00:00:00 EDT 2008
homeodomain transcription factor
