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Invitrogen
PIWIL2 Polyclonal Antibody
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Product Details
PA5-34341
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid synthetic peptide near the center of human PIWI-L2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human brain tissue lysate.
PA5-34341 can be used with blocking peptide PEP-1384.
Target Information
The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer/testis antigen 80; CT80; PIWI-L2; piwi-like 2; Piwi-like protein 2; PIWIL2; piwil2-like protein; PL2L106; PL2L80A; testicular tissue protein Li 141; unnamed protein product
Gene Aliases: CT80; HILI; mili; PIWIL1L; PIWIL2
UniProt ID: (Human) Q8TC59
Entrez Gene ID: (Human) 55124
regulation of translation
spermatogenesis
cell differentiation
germ-line stem cell population maintenance
gene silencing by RNA
piRNA metabolic process
negative regulation of circadian rhythm
oogenesis
rhythmic process
meiotic cell cycle
positive regulation of meiosis I
secondary piRNA processing
piRNA-mediated gene silencing by mRNA destabilization
transposable element silencing by heterochromatin formation
transposable element silencing by piRNA-mediated heterochromatin formation
transposable element silencing by mRNA destabilization
transposable element silencing by piRNA-mediated DNA methylation
positive regulation of cytoplasmic translation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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