A suggested positive control is human brain tissue lysate.
PA5-34341 can be used with blocking peptide PEP-1384.
PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.
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Protein Aliases: 80kDa PIWIL2 short isoform; Cancer/testis antigen 80; CT80; HILI; MILI; Miwi like; PIWI-L2; PIWI-like 2; Piwi-like protein 2; piwi-like RNA-mediated gene silencing 2; PIWIL1L; PIWIL2; piwil2-like protein; testicular tissue protein Li 141
Gene Aliases: CT80; HILI; mili; PIWIL1L; PIWIL2
UniProt ID: (Human) Q8TC59
Entrez Gene ID: (Human) 55124