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Invitrogen
PJA2 Polyclonal Antibody
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FIGURE: 1 / 2
PJA2 Antibody (PA5-35950) in IHC (P)
PJA2 Polyclonal Antibody detects PJA2 protein at membrane on mouse esophagus by immunohistochemical analysis. Sample: Paraffin-embedded mouse esophagus. PJA2 Polyclonal Antibody (Product # PA5-35950) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-35950
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human PJA2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Predicted reactivity: Human (99%), Mouse (99%), Rat (99%), Bovine (99%).
Target Information
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase Praja-2; E3 ubiquitin-protein ligase Praja2; KIAA0438; neurodegeneration associated protein 1; praja 2, RING-H2 motif containing; praja ring finger 2, E3 ubiquitin protein ligase; praja-2; Praja2; protein carrying the RING-H2 sequence motif; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2; unnamed protein product
Gene Aliases: AI447901; AL022700; KIAA0438; mKIAA0438; Neurodap1; PJA2; RNF131
UniProt ID: (Human) O43164, (Mouse) Q80U04
Entrez Gene ID: (Human) 9867, (Mouse) 224938
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
metal ion binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
inflammatory response
long-term memory
regulation of protein kinase A signaling
protein ubiquitination
positive regulation of toll-like receptor 2 signaling pathway
regulation of macrophage activation
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
positive regulation of JNK cascade
positive regulation of p38MAPK cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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