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PKA C alpha+beta Polyclonal Antibody
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Product Details
BS-2371R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PKA beta.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. PRKACB is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-alpha-s; alternatively spliced isoform; cAMP-dependent protein kinase C beta; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit beta; cAMP-dependent protein kinase catalytic subunit C alpha; PKA C-alpha; PKA C-beta; protein kinase A; protein kinase A catalytic subunit; protein kinase A catalytic subunit beta; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; protein kinase, cAMP-dependent, catalytic, beta; sperm cAMP-dependent protein kinase catalytic subunit; unnamed protein product
Gene Aliases: CAFD1; CAFD2; Cs-PKA; PKA C-beta; PKACA; PKACB; PKCA1; PKCD; PPNAD4; PRKACA; PRKACB
UniProt ID: (Human) P17612, (Human) P22694, (Mouse) P05132, (Rat) P68182, (Mouse) P68181
Entrez Gene ID: (Human) 5566, (Human) 5567, (Rat) 25636, (Mouse) 18747, (Rat) 293508, (Mouse) 18749
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
cAMP-dependent protein kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
protein domain specific binding
manganese ion binding
ubiquitin protein ligase binding
protein kinase A regulatory subunit binding
channel activator activity
protein serine kinase activity
Rab GTPase binding
protein complex binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
mesoderm formation
neural tube closure
regulation of heart rate
renal water homeostasis
mRNA processing
protein phosphorylation
protein export from nucleus
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of macroautophagy
peptidyl-serine phosphorylation
cytokine-mediated signaling pathway
cellular potassium ion homeostasis
cellular response to nutrient levels
positive regulation of insulin secretion
negative regulation of interleukin-2 production
high-density lipoprotein particle assembly
cellular response to heat
mitochondrial protein catabolic process
interleukin-2-mediated signaling pathway
TORC1 signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of cholesterol biosynthetic process
regulation of osteoblast differentiation
positive regulation of gluconeogenesis
negative regulation of smoothened signaling pathway
positive regulation of protein export from nucleus
sperm capacitation
positive regulation of phagocytosis
modulation of synaptic transmission
positive regulation of calcium-mediated signaling
regulation of cell cycle
regulation of cardiac muscle contraction
regulation of proteasomal protein catabolic process
cellular response to cold
regulation of protein processing
cellular response to glucose stimulus
cellular response to parathyroid hormone stimulus
cellular response to glucagon stimulus
cellular response to epinephrine stimulus
cell communication by electrical coupling involved in cardiac conduction
vascular endothelial cell response to laminar fluid shear stress
postsynaptic modulation of chemical synaptic transmission
cAMP/PKA signal transduction
regulation of cardiac conduction
negative regulation of TORC1 signaling
negative regulation of glycolytic process through fructose-6-phosphate
protein localization to lipid particle
regulation of bicellular tight junction assembly
signal transduction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
peptidyl-threonine phosphorylation
regulation of cellular respiration
protein autophosphorylation
negative regulation of meiotic cell cycle
regulation of synaptic transmission, glutamatergic
positive regulation of cell cycle arrest
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
phosphorylation
response to clozapine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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