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Immunogen sequence: EKLERKEIQP PYKPKARDKR DTSNFDKEFT RQPVELTPTD KLFIMNLDQN EFAGFSYTNP EFVIN
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3' end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: PKC-B; Protein kinase C beta type; protein kinase C, beta 1 polypeptide
Gene Aliases: PKC-beta; PKCB; PRKCB; PRKCB1; PRKCB2
UniProt ID: (Human) P05771
Entrez Gene ID: (Human) 5579
Molecular Function:
annexin
calcium-binding protein
calmodulin
intracellular calcium-sensing protein
kinase
non-receptor serine/threonine protein kinase
protein kinase
transfer/carrier protein
transferase
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