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Proteintech

PKC beta Polyclonal Antibody

6 References
View all (12) PKC beta antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

12919-1-AP

Applications Tested Dilution Publications

Western Blot (WB)

 1:1,000-1:3,000 View 3 publications 3 publications

Immunohistochemistry (IHC)

 - View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

 1:50-1:500 -

Immunoprecipitation (IP)

 0.5-4.0 µg -

Miscellaneous PubMed (Misc)

 - View 2 publications 2 publications
Product Specifications

Species Reactivity

 Human, Mouse, Rat

Published species

 Human, Rat

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

PKC beta Fusion Protein Ag3591 (342-598 aa encoded by BC036472)
View immunogen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 0.17 mg/mL

Purification

 Antigen affinity chromatography

Storage buffer

 PBS, pH 7.3, with 50% glycerol

Contains

 0.1% sodium azide

Storage conditions

 -20°C

Product Specific Information

Immunogen sequence: FNFLMVLGK GSFGKVMLSE RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALPGKP PFLTQLHSCF QTMDRLYFVM EYVNGGDLMY HIQQVGRFKE PHAVFYAAEI AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI KIADFGMCKE NIWDGVTTKT FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP FEGEDEDELF QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHA (342-598 aa encoded by BC036472)

Target Information

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: PKC-B; PKC-beta; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; protein kinase C beta-II; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide

Gene Aliases: A130082F03Rik; PKC-Beta; PKCB; PRKCB; PRKCB1; PRKCB2

UniProt ID: (Human) P05771, (Mouse) P68404, (Rat) P68403

Entrez Gene ID: (Human) 5579, (Mouse) 18751, (Rat) 25023

Molecular Function: non-receptor serine/threonine protein kinase protein modifying enzyme

Function(s)
response to hypoxia adaptive immune response transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein phosphorylation calcium ion transport cellular calcium ion homeostasis apoptotic process mitotic nuclear envelope disassembly signal transduction negative regulation of glucose transport peptidyl-serine phosphorylation platelet activation positive regulation of vascular endothelial growth factor receptor signaling pathway histone H3-T6 phosphorylation intracellular signal transduction B cell activation lipoprotein transport positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of angiogenesis negative regulation of insulin receptor signaling pathway B cell receptor signaling pathway positive regulation of B cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity cellular response to carbohydrate stimulus immune system process regulation of transcription, DNA-templated regulation of dopamine secretion phosphorylation chromatin modification regulation of growth response to drug response to glucose dibenzo-p-dioxin metabolic process response to vitamin D positive regulation of odontogenesis of dentin-containing tooth response to ethanol
Process(es)
chromatin binding protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity protein kinase C binding calcium channel regulator activity protein binding ATP binding zinc ion binding ligand-dependent nuclear receptor transcription coactivator activity histone kinase activity (H3-T6 specific) histone binding androgen receptor binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding
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