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Invitrogen

PKC beta Polyclonal Antibody

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PKC beta Polyclonal Antibody

Product Details

PA5-142915

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.3 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence C-DKEFTRQPVELT (aa 631-642).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2933558

Product Specific Information

Additional Information: This antibody is expected to recognize isoform 1 (NP_997700.1) only.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

Target Information

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: PKC-B; PKC-beta; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; unnamed protein product

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Gene Aliases: PKC-beta; PKCB; PKCbeta; PKCI(2); PRKCB; PRKCB1; PRKCB2

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UniProt ID: (Human) P05771, (Rat) P68403

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Entrez Gene ID: (Human) 5579, (Rat) 25023

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Function(s)
nucleotide binding chromatin binding transcription coactivator activity protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity protein kinase C binding calcium channel regulator activity protein binding ATP binding zinc ion binding kinase activity transferase activity histone kinase activity (H3-T6 specific) histone binding metal ion binding androgen receptor binding protein serine kinase activity ligand-dependent nuclear receptor transcription coactivator activity non-receptor serine/threonine protein kinase protein modifying enzyme
Process(es)
adaptive immune response immune system process chromatin organization chromatin remodeling regulation of transcription from RNA polymerase II promoter protein phosphorylation calcium ion transport cellular calcium ion homeostasis apoptotic process mitotic nuclear envelope disassembly signal transduction phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway regulation of glucose transport negative regulation of glucose transport positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of insulin secretion intracellular signal transduction B cell activation lipoprotein transport positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of angiogenesis positive regulation of transcription, DNA-templated negative regulation of insulin receptor signaling pathway B cell receptor signaling pathway regulation of transport protein kinase C signaling cellular response to carbohydrate stimulus presynaptic modulation of chemical synaptic transmission regulation of synaptic vesicle exocytosis response to hypoxia transcription, DNA-templated response to glucose regulation of dopamine secretion dibenzo-p-dioxin metabolic process response to vitamin D histone H3-T6 phosphorylation regulation of growth positive regulation of odontogenesis of dentin-containing tooth response to drug response to ethanol positive regulation of B cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity
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